Thank you for RAISING HOPE®
for how sick children are treated

On average, a Canadian child receives four prescriptions a year but the majority of drugs do not have dosage or safety data. Adverse drug reactions in children can lead to long-term health problems or death.

At Children’s Health Research Institute, scientists are focusing on how a child’s system moves drugs in and out of the body. This means that drugs can be prescribed based on the child’s individual need and ability to safely take medication.

Your support is helping our research succeed.

Some of the successful achievements to date:

• The Ifosfamide project – ifosfamide is a chemotherapy drug that can cause kidney failure. Over the past two years, researchers have been exploring a strategy that will allow children with cancer to receive this drug while at the same time receiving a protective therapy that prevents them from sustaining kidney damage. This work is at the stage where London is leading a team of collaborators from across Canada to conduct a large-scale clinical trial to validate the results.
• There are wide variations in the blood concentration of children who are given the same dosage of corticosteroids – potent drugs commonly used in the therapy of asthma, arthritis and other inflammatory conditions. The implication is that the current dosing of this drug may put children at significant risk and work is under way to determine how genetic markers will help guide a personalized approach to corticosteroid therapy.  

Researchers at Children’s Health Research Institute (CHRI) are focusing their work on drug-related risk factors in children with the potential to revolutionize paediatric care and treatment. The primary focus is personalized drug therapy for children with the goal of giving the right drug, at the right time, to the right child.

Donate Now

With your help, we can help revolutionize how sick children are treated. Donate Now.

For the complete Donor Update on Personalized Paediatric Medicine click here.